Endocrine Abstracts

Background: Childhood obesity is increasing worldwide and presents as a global health issue due to multiple metabolic comorbidities. About 1% of adolescents with obesity develop type 2 diabetes (T2D), however little is known about the genetic background in young age. The objective of this study was to assess the prevalence of impaired glucose regulation (IGR) in a large cohort of children and adolescents with obesity and to characterize insulin sensitivity and insulin secretio...

Background: Obesity is a rising problem in developed and developing countries. Currently little is known about prevalence and prognosis of type 2 diabetes and the metabolic syndrome in obese children and adolescents in Europe.Patients and methods: About 491 obese children (mean-age 11.2 years; mean-BMI 30.3 kg/m2) were examined (lipid-profile; blood pressure, insulin-resistance1) and in 102 of them with risk factors for type 2 diabe...